The strength of clinical evidence is recoverable from language model representations but not from their stated grades
This paper evaluates the ability of large language models to recover and express evidence grades from clinical claims, finding that while they can recover the grades, they do not consistently express them.
This paper is novel in its evaluation of large language models' ability to recover and express evidence grades from clinical claims.
Before reading this…
Applications
- →Improving the accuracy and consistency of large language models in understanding and expressing evidence grades in clinical claims.
To understand this paper, make sure you know these concepts first:
- Understanding of large language models and clinical claims.find papers →
- Familiarity with evidence grades and their importance in clinical research.find papers →
Abstract
More Like ThisLarge language models (LLMs) increasingly summarize clinical evidence, where a claim's weight depends on how strongly it is supported. Yet these models convey confidence poorly, and properties they never state, such as truth, are often readable from their activations. Whether a clinical model registers evidence strength, distinct from truth, and states it when asked is untested, and any such signal could be lexical. We compiled 45,134 clinical claims from six public sources, harmonized 20,611 into a four-level evidence grade under three independent frameworks, and tested 22 local, open-weight LLMs from several developers (0.6-70 billion parameters; general, medical, and reasoning), with lexical, truth, and cross-framework controls. A linear estimator recovered the grade in every model (median AUROC 71.8), yet decodability did not rise with scale and was weakest in reasoning models. The grade the models stated fell to chance, 25-27 percentage points below the estimator. The recoverable signal was largely lexical and did not transfer across topics or frameworks, yet it was distinct from factual truth and still flagged weakly supported claims (AUROC 69.2). Clinical LLMs thus carry an ordered evidence-strength signal they do not express, so their stated grades fail to convey a claim's support even when it is recoverable from their representations and text.