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20 results for “mRNA expression”

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eess.IVcs.CVEmpiricalRecentJun 12, 2026

Trimodal Glioma Representation Alignment via Volumetric Contrastive Learning

Denise Marini, Eleonora Grassucci, Danilo Comminiello

This paper introduces GLORIA, a novel framework for aligning and fusing histopathology, mRNA expression, and magnetic resonance imaging data for glioma grading and survival prediction.

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cs.LGcs.AIRecentMay 31, 2026

Plausibility Is Not Prediction: Contrastive Evidence for LLM-Based Cellular Perturbation Reasoning

Xinyu Yuan, Xixian Liu, Jianan Zhao, Yashi Zhang +2 more

The paper introduces CORE, a contrastive evidence organization method, which significantly improves the accuracy of LLM-based predictions of gene expression changes following cellular perturbations by…

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q-bio.QMcs.HCEmpiricalRecentJul 24, 2026

Loom: Multi-Region Analysis of Spatial Transcriptomics with Local Neighborhoods and Global Trajectories

Siyuan Zhao, Nafiul Nipu, Hossein Fathollahian, Olga Karginova +3 more

Loom is a system for analyzing spatial transcriptomics data through detailed pseudo-temporal exploration, cross-sample comparisons, and investigation of spatiotemporal biological mechanisms.

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cs.CLRecentMay 30, 2026

ProtStructQA: A Denotation Threshold in Protein Structural Reasoning

Aravind Mandiga, Guoming Li, Jin Lu, Ismailcem Budak Arpinar +2 more

The paper introduces ProtStructQA, an executable benchmark that tests protein structural reasoning by requiring language models to generate measurable 3D coordinates, revealing a capability-dependent…

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eess.ASEmpiricalRecentJul 9, 2026

Multimodal Digital Biomarker for Asthma: Complementary Roles of Vocal, Clinical and Demographic Factors

Vladimir Despotovic, Milena Despotovic, Abir Elbeji, Petr V. Nazarov +1 more

A multimodal Mixture-of-Experts framework was developed for asthma detection using vocal biomarkers and clinical data, achieving better performance than unimodal and bimodal approaches.

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cs.AIRecentMay 30, 2026

Ryze: Evidence-Enriched Data Synthesis from Biomedical Papers

Yeqi Huang, Yue Chen, Yanwei Ye, Guanhao Su +1 more

The paper introduces Ryze, an automated system that synthesizes evidence-enriched Question-Answering (QA) pairs from raw biomedical papers, resulting in a specialized VLM (BioVLM-8B) that significantl…

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cs.ITTheoreticalRecentJun 19, 2026

Error Exponent Bounds for Optimal Short-Read Clustering

Yoav Chachamovitz, Nir Weinberger

This paper derives bounds on the probability of incorrect clustering of noisy short sequences using statistically optimal rules, focusing on DNA storage decoders.

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q-bio.BMcs.AIRecentMay 29, 2026

AMix-2: Establishing Protein as a Native Modality in Large Language Models

Keyue Qiu, Yixin Wu, Lihao Wang, Yawen Ouyang +18 more

The paper introduces AMix-2, a novel protein-text foundation model that unifies protein understanding and sequence design by embedding both modalities in a shared token space, achieving state-of-the-a…

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cs.CVcs.AIcs.LGRecentJun 1, 2026

GC-MoE: Genomics-Guided Cell-Type-Specific Mixture of Experts for Histology-Based Single-Cell Spatial Transcriptomics

Kaito Shiku, Ahtisham Fazeel Abbasi, Ryoma Bise, Yuichiro Iwashita +3 more

The paper proposes GC-MoE, a novel framework that uses a Mixture-of-Experts approach guided by genomics to accurately predict cell-type-specific gene expression for individual cells from histopatholog…

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cs.LGcs.AIcs.NERecentMay 27, 2026

BIRDNet: Mining and Encoding Boolean Implication Knowledge Graphs as Interpretable Deep Neural Networks

Tirtharaj Dash

BIRDNet is a novel, sparse, and interpretable deep neural network that encodes Boolean implication knowledge mined directly from tabular data, achieving performance comparable to dense models while dr…

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cs.CLcs.AIcs.LGRecentMay 27, 2026

Where Does Toxicity Live? Mechanistic Localization and Targeted Suppression in Language Models

Himanshu Beniwal, Mayank Singh

The paper introduces retraining-free frameworks (Meow2X and TRNE) that mechanistically localize and suppress toxicity within language models by analyzing activation differences, achieving safety impro…

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q-bio.BMcs.ARcs.ETEmpiricalRecentJun 15, 2026

Energy-efficient codon optimization on thermodynamic hardware

Andraz Jelincic, Ross C. Walker

This paper presents the first application of thermodynamic computing to mRNA codon optimization in pharmaceutical R&D, achieving significant energy savings compared to conventional GPUs.

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cs.LGcs.AIRecentMay 27, 2026

Influence-Guided Symbolic Regression: Scientific Discovery via LLM-Driven Equation Search with Granular Feedback

Evgeny S. Saveliev, Samuel Holt, Nabeel Seedat, David L. Bentley +2 more

The paper introduces Influence-Guided Symbolic Regression (IGSR), a novel framework that uses granular influence scores to guide LLMs in efficiently searching for and discovering complex mathematical…

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cs.IRcs.CLDatasetRecentJun 9, 2026

A PubMed-Scale Dataset of Structured Biomedical Abstracts

Chia-Hsuan Chang, Haerin Song, Brian Ondov, Hua Xu

The authors introduce Structured PubMed, a comprehensive corpus of section-labeled biomedical abstracts compiled from the complete PubMed database.

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cs.CVcs.AIcs.HCRecentMay 30, 2026

CodeCytos: AI-assisted spatial molecular imaging analysis via code-augmented agent action space

Hung Q. Vo, Huy Q. Vo, Son T. Ly, Zhihao Wan +5 more

CodeCytos is a novel coding-based reasoning agent framework that enables dynamic, programmable interaction with spatial molecular imaging data, significantly improving the automation and customization…

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cs.CRRecentApr 30, 2026

Secure Cross-Silo Synthetic Genomic Data Generation

Daniil Filienko, Martine De Cock, Sikha Pentyala

The paper proposes a novel framework that enables multiple institutions to jointly train a synthetic genomic data generator without revealing their raw data, thereby facilitating large-scale, privacy-…

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cs.AIEmpiricalRecentJul 16, 2026

AutoSynthesis: An agentic system for automated meta-analysis

Moein Taherinezhad, Sebastian Maier, Gerardo Vitagliano, Francesco Pierri +1 more

AutoSynthesis is an end-to-end multi-agent system for automated meta-analysis in evidence synthesis, including search strategy formulation, literature retrieval, screening, eligibility assessment, sta…

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